Document Type

Journal Article

Publication Title

Journal of Musculoskeletal Neuronal Interactions

ISSN

11087161

Volume

20

Issue

3

First Page

347

Last Page

371

PubMed ID

32877972

Publisher

Hylonome Publications

School

Exercise Medicine Research Institute / School of Medical and Health Sciences

RAS ID

31511

Comments

Hart, N. H., Newton, R. U., Tan, J., Rantalainen, T., Chivers, P., Siafarikas, A., & Nimphius, S. (2020). Biological basis of bone strength: anatomy, physiology and measurement. Journal of Musculoskeletal and Neuronal Interactions, 20(3). http://www.ismni.org/jmni/index.php

Abstract

© 2020, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved. Understanding how bones are innately designed, robustly developed and delicately maintained through intricate anatomical features and physiological processes across the lifespan is vital to inform our assessment of normal bone health, and essential to aid our interpretation of adverse clinical outcomes affecting bone through primary or secondary causes. Accordingly this review serves to introduce new researchers and clinicians engaging with bone and mineral metabolism, and provide a contemporary update for established researchers or clinicians. Specifically, we describe the mechanical and non-mechanical functions of the skeleton; its multidimensional and hierarchical anatomy (macroscopic, microscopic, organic, inorganic, woven and lamellar features); its cellular and hormonal physiology (deterministic and homeostatic processes that govern and regulate bone); and processes of mechanotransduction, modelling, remodelling and degradation that underpin bone adaptation or maladaptation. In addition, we also explore commonly used methods for measuring bone metabolic activity or material features (imaging or biochemical markers) together with their limitations.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

Research Themes

Health

Priority Areas

Multidisciplinary biological approaches to personalised disease diagnosis, prognosis and management

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