Title

Circulating melanoma cells relative to disease stage

Author Identifiers

Melanie Ziman

Researcher ID: A-2272-2008

Scopus: 7004240195

Collection Type

Dataset

Faculty

Faculty of Computing Health and Science

School or Research Centre

School of Exercise, Biomedical and Health Sciences

Contact

m.ziman@ecu.edu.au

Publisher

Edith Cowan University Research Online

Funders

National Health and Medical Research Council, Cancer Council of Western Australia, Cancer and Palliative Care Research and Evaluation Unit

Dataset Identifier

http://hdl.handle.net/102.100.100/6843

Description

This collection comprises clinical data with four-five melanoma markers per patient. collected over three years of data comprising genetic tests, clinical data and clinical evaluations. The dataset includes names of genes being investigated: by clinical stage of metastasis, and by drug treatments and is stored in Excel file format. The dataset supports research on the PAX3 gene and its role as a key regulator of the myriad steps in melanocytic cell determination. The purpose of the research is (1) to identify the transcriptional profile of circulating melanoma cells relative to disease stage and (2) to test the efficacy of using circulating cells as a prognostic marker. The data has the potential to be used by others to correlate new research data using different methodologies.

Additional Information

The research was funded by three grants from the NHMRC (National Health and Medical Research Council), the Cancer Council of WA and the Cancer and Palliative Care Research and Evaluation Unit.

ECU Melanoma Research Group - http://www.ecu.edu.au/schools/exercise-biomedical-and-health-sciences/research-activity/ecu-melanoma-research-group

FoR Codes

111201, 111202, 111203

Research Activity Title

Characterisation of circulating melanoma cells in patient blood

Research Activity Description

Melanoma is a highly aggressive form of skin cancer that has a tendency to metastasise. It accounts for around 80% of skin cancer related deaths. In its early stages, the 5 year survival rate of patients is greater than 90% following surgical excision of an in situ tumour. However, following metastasis of the tumour, the 5 year survival rate declines to 5-35%. Due to the correlation between metastasis and declining survival, research studies have attempted to identify potential metastasis as early as possible. The Melanoma Research Group at Edith Cowan University (ECU) is developing a blood test for diagnosis and prognosis of melanoma. Thus far the ECU researchers have developed a test that can detect circulating melanoma cells in peripheral blood of patients. The test can be used for diagnostic purposes and has been tested in over 250 patients with a 79% detection rate. Development of a prognostic blood test that can detect melanoma cells at early stages of the disease has the potential to benefit all melanoma sufferers and potential melanoma sufferers.

Start of data collection time period

January 2009

End of data collection time period

December 2011

Language

eng

Access Rights

Edith Cowan University owns the rights to this collection.

Contact Dr Mel Ziman to determine access conditions.

This document is currently not available here.

Share

Article Location

 
COinS