Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels

Document Type

Journal Article

Publisher

IOS Press

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science

RAS ID

5921

Comments

Wahjoepramono, E. J., Wijaya, L. K., Taddei, K. , Martins, G. S., Howard, M. T., De Ruyck, K. , Bates, K. A., Dhaliwal, S., Verdile, G. , Carruthers, M., & Martins, R. N. (2008). Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels. Journal of Alzheimer's Disease, 15(1), 129-137. Available here

Abstract

The effect of testosterone on the levels of the Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated guinea pigs (GPX) were administered testosterone at two different dosages, following which plasma and cerebrospinal fluid (CSF) Aβ_{40} levels were measured. Plasma Aβ_{40} levels were reduced in GPX in the early stages of low-dose testosterone treatment, whereas CSF Aβ_{40} levels were only reduced by the time circulating testosterone had returned to untreated GPX levels. The supraphysiological testosterone dose did not reduce CSF Aβ_{40} levels significantly until circulating testosterone was back to uncastrated levels, whereas plasma Aβ_{40} levels significantly increased over time in these animals. These results indicate that the extent of testosterone-induced changes to Aβ_{40} levels and their response rates depend on both the tissue examined and testosterone dosage.

DOI

10.3233/JAD-2008-15111

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Link to publisher version (DOI)

10.3233/JAD-2008-15111