Cardiovascular and Metabolic Complications During Androgen Deprivation: Exercise as a Potential Countermeasure
Document Type
Journal Article
Publisher
Nature Publishing Group
Faculty
Faculty of Computing, Health and Science
School
Vario Health Institute / Centre for Exercise and Sports Science Research
RAS ID
9182
Abstract
Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.
DOI
10.1038/pcan.2009.12
Access Rights
free_to_read
Comments
Galvao, D. A., Taaffe, D., Spry, N., Joseph, D., & Newton, R. (2009). Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure. Prostate Cancer and Prostatic Diseases , 12, 233-40. Available here