Title

Cardiovascular and Metabolic Complications During Androgen Deprivation: Exercise as a Potential Countermeasure

Document Type

Journal Article

Publisher

Nature Publishing Group

Faculty

Computing, Health and Science

School

Vario Health Institute, Centre for Exercise and Sports Science Research

RAS ID

9182

Comments

This article was originally published as: Galvao, D. A., Taaffe, D., Spry, N., Joseph, D., & Newton, R. (2009). Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure. Prostate Cancer and Prostatic Diseases , 12, 233-40. Original article available here

Abstract

Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.

 

Link to publisher version (DOI)

10.1038/pcan.2009.12