Title

Molecular and Cellular Basis for Anti-Amyloid Therapy in Alzheimer Disease

Document Type

Journal Article

Publisher

Lippincott, Williams and Wilkins

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science

RAS ID

2086

Comments

This article was originally published as: Gandy, S., Martins, R. N., & Buxbaum, J. (2003). Molecular and Cellular Basis for Anti-Amyloid Therapy in Alzheimer Disease. Alzheimer Disease and Associated Disorders, 17(4), 259-266. Original article available here

Abstract

AIzheimer disease (AD) is characterized by clinical evidence of cognitive failure in association with cerebral amyloidosis, as well as cerebral intraneuronal neurofibrillary pathology, neuronal and synaptic loss, and neurotransmitter deficits. The cerebral amyloid of AD is deposited around meningeal and cerebral vessels, as well as in gray matter. In gray matter, the deposits are multifocal, coalescing into miliary structures known as plaques. Parenchymal amyloid plaques are distributed in brain in a characteristic fashion, differentially affecting the cerebrum and hippocampus, while largely sparing the basal ganglia, thalamus, spinal cord, and hindbrain.