Title

A Dorso-Ventral Gradient of Pax6 in the Developing Retina Suggests a Role in Topographic Map Formation

Document Type

Journal Article

Publisher

Elsevier

Faculty

Computing, Health and Science

School

Exercise, Biomedical and Health Science

RAS ID

2101

Comments

This article was originally published as: Ziman, M. R., Rodger, J., Lukehurst, S., Hancock, D., Dunlop, S., & Beazley, L. (2003). A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation. Developmental Brain Research, 140(2), 299-302. Original article available here

Abstract

Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal projection.

DOI

10.1016/S0165-3806(02)00605-3

 

Link to publisher version (DOI)

10.1016/S0165-3806(02)00605-3