Title

Spinal muscular atrophy among the Roma (Gypsies) in Bulgaria and Hungary

Document Type

Journal Article

Publisher

Elsevier Science

Faculty

Computing, Health and Science

School

Biomedical and Sports Science

RAS ID

256

Comments

Originally published as: Jordanova, A., Kargaci, V., Kremensky, I., Litvinenko, I., Uzunova, M., Turnev, I., ... & Kalaydjieva, L. (2002). Spinal muscular atrophy among the Roma (Gypsies) in Bulgaria and Hungary. Neuromuscular Disorders, 12(4), 378-385. Original article available here.

Abstract

Spinal muscular atrophy is one of the most common autosomal recessive disorders, classified into three major clinical forms. It is caused mainly by deletions or gene conversions of the telomeric survival motor neuron gene (SMN1) on human chromosome 5. We have conducted molecular studies of the disorder in genetically isolated Romani (Gypsy) communities in Bulgaria and Hungary, where spinal muscular atrophy appears to have different prevalence and both mild and severe spinal muscular atrophy phenotypes have been diagnosed. We have observed three distinct genetic defects which, in different combinations, lead to different forms of the disease. The similar chromosomal background on which the different mutations occur suggests a common origin and founder effect, with rearrangements of a single ancestral chromosome resulting in a diversity of molecular defects.

DOI

10.1016/S0960-8966(01)00283-8

 
COinS
 

Link to publisher version (DOI)

10.1016/S0960-8966(01)00283-8