Dietary carbohydrate and cholesterol influence the number of particles and distributions of lipoprotein subfractions in guinea pigs
Computing, Health and Science
School of Exercise, Biomedical and Health Science, Centre for Alzheimer's Disease
Guinea pigs (n=10/group) were fed one of three diets: a high carbohydrate (CHO) (42% energy), low cholesterol (0.04%) diet (LChHC), a diet with the same amount of CHO but with 0.25% cholesterol (HChHC) or a diet with 11% of energy from CHO and 0.25% cholesterol (HChLC) for 12 weeks. VLDL- and LDL cholesterol (LDL-C) were higher in the HChLC and HChHC groups than in the LChHC group (P60 nm) and the medium VLDL (>35 nm) in the high cholesterol groups (P8.2 nm) and small HDL (>7.2 nm) was higher in the HChHC and HChLC groups (P19.8 nm) (98.4±90.8) and small LDL (>18 nm) (29.3±24.9 nmol/L) were lower in the HChLC group than in the HChHC group (261.8±105.8 and 64.9±27.9 nmol/L, respectively). These results indicate that dietary cholesterol increased the atherogenicity of both VLDL and HDL while CHO restriction increased the number of large LDL and decreased the concentrations of the more atherogenic smaller LDL subfractions.