Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers
Authors
Simon Lau, Edith Cowan University
Kristyn Alissa Bates, Edith Cowan University
Hamid R. Sohrabi, University of Western Australia
Mark Rodrigues, Edith Cowan University
Georgia Martins, Edith Cowan University
Satvinder S. Dhaliwal, Curtin University
Kevin Taddei, Edith Cowan UniversityFollow
Simon M. Laws, Edith Cowan UniversityFollow
Ian J. Martins, Edith Cowan UniversityFollow
Francis L. Mastaglia, University of Western Australia
Jonathan K. Foster, Edith Cowan University
Jacqueline K. Phillips, Murdoch University
Ralph N. Martins, Edith Cowan University
Document Type
Journal Article
Publisher
Elsevier
Faculty
Faculty of Health, Engineering and Science
School
School of Exercise, Biomedical and Health Science / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
10543
Abstract
A number of genetic risk factors have been identified for Alzheimer’s disease (AD) including genes involved in the inflammatory response (interleukin 1A, [IL-1 (-889)], interleukin 1B (IL-1 [ 3953]), and tumor necrosis factor (TNF [-308 and -850]). We investigated the prevalence and functional consequences (baseline cognitive performance, plasma cytokine levels) of possession of these putative genetic risk factors within a group of subjective memory complainers (SMC, n 226) and age and sex matched noncomplainers (NMC, n 167). We observed no effect of any of the genetic factors investigated on cognitive performance. Further, there was no difference in the frequency of the disease-associated alleles, or cytokine levels between subjective memory complainers and noncomplainer participants. There was no relationship between TNF polymorphisms and TNF levels. There was a significant increase in plasma IL-1 levels in those homozygous for the disease-associated allele (i.e., IL-1 3953 TT). Follow-up longitudinal assessments on this cohort will provide insight as to how these polymorphisms may affect the risk of cognitive decline over time.
DOI
10.1016/j.neurobiolaging.2010.09.003
Access Rights
free_to_read
Comments
Lau, S. , Bates, K. A., Sohrabi, H. R., Rodrigues, M., Martins, G., Dhaliwal, S.S., Taddei, K. , Laws, S.M., Martins, I. J., Mastaglia, F.L., Foster, J. K., Phillips, J.K., & Martins, R. N. (2012). Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiology of Aging, 33 (6),1054-1056.
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