Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Document Type

Journal Article

Publisher

Elsevier Inc.

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence for Alzheimer's Disease Research and Care

RAS ID

10677

Comments

Miklossy, J., Qing, H., Radenovic, A., Kis, A., Vileno, B., Laszlo, F., Miller, L., Martins, R. N., Waeber, G., Mooser, V., Bosman, F., Khalili, K., Darbinian, N., & McGeer, P. (2010). Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging, 31(9), 1503-1515. Available here

Abstract

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes, To determine if amyloid beta (AP) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (IO type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS~ I) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated AB. hyperphosphorylated rau, ubiquilin, apolipoprotein E. apolipoprotein(a), IBI/JlP-1 and JNKI were detected in Langerhans islets in type 2 diabetic patients. AB was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that AP deposits und hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes und suggesting that AB deposits and hyperphosphorylated tau may also occur in other organs than the brain.

DOI

10.1016/j.neurobiolaging.2008.08.019

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2008.08.019