Frontotemporale Lobardegenerationen, Teil 2: Bildgebung, Neuropathologie und Genetik

Document Type

Journal Article

Publisher

Georg Thieme Verlag

Faculty

Faculty of Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

7639

Comments

Diehl-Schmid, J., Neumann, M., Laws, S. , Perneczky, R., Grimmer, T., Danek, A., Riemenschneider, M., Kurz, A., & Forstl, H. (2009). Frontotemporale Lobardegenerationen, Teil 2: Bildgebung, Neuropathologie und Genetik. Fortschritte der Neurologie, Psychiatrie, 77(5), 295-304. Available here

Abstract

Frontotemporal Lobar Degeneration (FTLD) is clinically heterogeneous, less common than Alzheimer's disease (AD), and - if at all - usually diagnosed in the presenium. The most common form, frontotemporal dementia (FTD) is characterized by changes in behaviour and personality, the less common progressive aphasia (PA) by a non-fluent aphasia and semantic dementia (SD) primarily by a loss of vocabulary and concepts. The diagnosis can be very difficult to make and therefore usually made only several years after the occurrence of the first ambiguous symptoms. The diagnosis relies on clinical criteria, including a neuropsychological collection of executive and language skills. Current therapeutic interventions aim at treating the symptomology, as no cure currently exists. Very important is the guidance and support of family members especially in patients with FTD, which are often exposed to an even greater burden than the relatives of patients with AD.

DOI

10.1055/s-0028-1109107

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Link to publisher version (DOI)

10.1055/s-0028-1109107