No Association of Tachykinin Receptor 2 (TACR2) Polymorphisms with Alzheimer's Disease

Document Type

Journal Article

Publisher

Elsevier

Faculty

Faculty of Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

18204

Comments

Friedrich, P., Feulner, T., Laws, S. , Eckart, K., Perneczky, R., Kurz, A., Forstl, H., & Riemenschneider, M. (2009). No association of Tachykinin Receptor 2 (TACR2) Polymorphisms with Alzheimer's disease. Neurobiology of Aging, 32(3) 544 - 545. Available here

Abstract

The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in stress induced hippocampal acetylcholine release and the gene TACR2 is located within a previously identified linkage region for Alzheimer’s disease (AD) on chromosome 10q21. Together, both facts make the TACR2 a reasonable positional and functional candidate gene for AD. Genotyping of 13 single nucleotide polymorphisms (SNPs) covering the entire gene and haplotypic analysis revealed no association with AD. Thus, we conclude that TACR2 can be excluded as a major susceptibility gene conferring risk to AD.

DOI

10.1016/j.neurobiolaging.2009.03.007

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2009.03.007