Document Type
Journal Article
Faculty
Faculty of Computing, Health and Science
School
School of Medical Sciences
RAS ID
12639
Abstract
Pax genes encode a family of transcription factors that have long been recognised as obligate contributors to embryonic development of the CNS, with evidence obtained from various animal models illustrating phylogenetically conserved functions. Within the CNS, Pax genes play substantial roles in cellular and regional specification, proliferation, progenitor cell maintenance, anti-apoptosis and neural differentiation. This comprehensive review details the critical functions of those Pax genes involved in pre- and post-natal CNS development, provides possible molecular mechanisms by which Pax genes contribute to proliferation and differentiation of neuronal cells, and explains observed changes in Pax gene expression in response to neurotrauma in the mature animal. Knowledge of the ability of individual Pax genes to specify precise lineages within the CNS is beneficial for cell replacement strategies, particularly in the production of ‘‘designer’’ cells for the treatment of neurodegenerative disorders. The manipulation of stem or committed cells so that they express definitive Pax genes may indeed assist in the pursuit of the holy grail of regenerative medicine – that of CNS cell replacement therapies leading to functional repair. We explain here, however, that only the sophisticated and precise use of Pax genes will lead to a successful outcome.
DOI
10.1016/j.pneurobio.2011.08.012
Access Rights
free_to_read
Comments
This is an Author's Accepted Manuscript of: Thompson, J. A., & Ziman, M. R. (2011). Pax genes during neural development and their potential role in neuroregeneration. Progress in Neurobiology, 95(3), 334-351. Available here