Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?
Document Type
Journal Article
Publisher
IOS Press
Faculty
Faculty of Computing, Health and Science
School
School of Medical Sciences
RAS ID
12622
Abstract
This commentary addresses a novel mechanism by which aging-related changes in reproductive hormones could mediate their action in the brain. It presents the evidence that dyotic endocrine signals modulate the expression of tumor necrosis factor (TNF) and related cytokines, and that these cytokines are a functionally important downstream link mediating neurodegeneration and dysfunction. This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases.
DOI
10.3233/JAD-2011-110887
Access Rights
subscription content
Comments
Clark, I., & Atwood, C. (2011). Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?. Journal of Alzheimer's Disease, 27(4), 691-699. Available here