Title

Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?

Document Type

Journal Article

Publisher

IOS Press

Faculty

Faculty of Computing, Health and Science

School

School of Medical Sciences

RAS ID

12622

Comments

This article was originally published as: Clark, I., & Atwood, C. (2011). Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?. Journal of Alzheimer's Disease, 27(4), 691-699. Original article available here

Abstract

This commentary addresses a novel mechanism by which aging-related changes in reproductive hormones could mediate their action in the brain. It presents the evidence that dyotic endocrine signals modulate the expression of tumor necrosis factor (TNF) and related cytokines, and that these cytokines are a functionally important downstream link mediating neurodegeneration and dysfunction. This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases.

DOI

10.3233/JAD-2011-110887

 

Link to publisher version (DOI)

10.3233/JAD-2011-110887