Document Type

Journal Article

Publisher

PLOS ONE

Faculty

Faculty of Health, Engineering and Science

School

School of Computer and Security Science

RAS ID

15225

Comments

This article was orginally published as : Peng C, Chen Y, Shan Y, Zhang H, Guo Z, et al. (2012) LSK Derived LSK- Cells Have A High Apoptotic Rate Related To Survival Regulation Of Hematopoietic and Leukemic Stem Cells. PLoS ONE 7(6). Original article available here

Abstract

A balanced pool of hematopoietic stem cells (HSCs) in bone marrow is tightly regulated, and this regulation is disturbed in hematopoietic malignancies such as chronic myeloid leukemia (CML). The underlying mechanisms are largely unknown. Here we show that the LinSca-1+c-Kit- (LSK) cell population derived from HSC-containing LinSca-1+c-Kit+ (LSK) cells has significantly higher numbers of apoptotic cells. Depletion of LSK cells by radiation or the cytotoxic chemical 5-fluorouracil results in an expansion of the LSK population. In contrast, the LSK population is reduced in CML mice, and depletion of leukemia stem cells (LSCs; BCR-ABL-expressing HSCs) by deleting Alox5 or by inhibiting heat shock protein 90 causes an increase in this LSK population. The transition of LSK to LSK cells is controlled by the Icsbp gene and its downstream gene Lyn, and regulation of this cellular transition is critical for the survival of normal LSK cells and LSCs. These results indicate a potential function of the LSK cells in the regulation of LSK cells and LSCs.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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