Within-laboratory and between-laboratory variability in the measurement of anti-mullerian hormone determined within an external quality assurance scheme

Document Type

Journal Article

Publisher

Elsevier Urban & Partner

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences

RAS ID

17396

Comments

Zuvela, E., Walls, M., & Matson, P. L. (2013). Within-laboratory and between-laboratory variability in the measurement of anti-mullerian hormone determined within an external quality assurance scheme. Reproductive Biology, 13(3), 255-257. Available here

Abstract

Ten laboratories in an external quality assurance scheme used the same assay to measure anti-müllerian hormone concentration (Beckman Coulter Gen II) and received twenty serum samples distributed over a 15 month period. The mean bias for all results was only −0.089%, but there was large coefficient of repeatability of 38.8% (sample bias ranged from −37.9% to +54.7%). While each laboratory showed good reproducibility, there was a wide range of average values relative to the consensus value from −24.0% to +22.7%. This between-laboratory variability suggests clinicians should use the same laboratory to avoid problems with result interpretation.

DOI

10.1016/j.repbio.2013.04.005

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