Title

Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity

Document Type

Journal Article

Publisher

Springer Verlag

Faculty

Faculty of Health, Engineering and Science

School

School of Exercise and Health Sciences

RAS ID

12674

Comments

This article was originally published as: Yonker, J. A.., Chang, V., Roetker, N. S., Hauser, T. S., Hauser, R. M. & Atword, C. S. (2013) Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity. Age, 35(1) 129-138. The final publication is available at Springer here

Abstract

The reproductive-cell cycle theory of aging posits that reproductive hormone changes associated with menopause and andropause drive senescence via altered cell cycle signaling. Using data from the Wisconsin Longitudinal Study (n = 5,034), we analyzed the relationship between longevity and menopause, including other factors that impact "ovarian lifespan" such as births, oophorectomy, and hormone replacement therapy. We found that later onset of menopause was associated with lower mortality, with and without adjusting for additional factors (years of education, smoking status, body mass index, and marital status). Each year of delayed menopause resulted in a 2.9% reduction in mortality; after including a number of additional controls, the effect was attenuated modestly but remained statistically significant (2.6% reduction in mortality). We also found that no other reproductive parameters assessed added to the prediction of longevity, suggesting that reproductive factors shown to affect longevity elsewhere may be mediated by age of menopause. Thus, surgical and natural menopause at age 40, for example, resulted in identical survival probabilities. These results support the maintenance of the hypothalamic- pituitary-gonadal axis in homeostasis in prolonging human longevity, which provides a coherent framework for understanding the relationship between reproduction and longevity.

DOI

10.1007/s11357-011-9342-1

Access Rights

free_to_read

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