Document Type
Journal Article
Publication Title
Investigative Ophthalmology and Visual Science
Publisher
ARVO Journals
School
School of Medical and Health Sciences / Centre for Precision Health
RAS ID
62099
Funders
Edith Cowan University / Cancer Concil of Western Australia / Australian National Health and Medical Research Council Career Development Fellowship
Grant Number
NHMRC Number : MRF1142962
Abstract
Purpose: The purpose of this study was to estimate the incidence and mortality of conjunctival melanoma in Australia from 1982 to 2014. Methods: De-identified unit data for all cases of ocular melanoma were extracted from the Australian Cancer Database from 1982 to 2014. Conjunctival melanoma cases were extracted, and the incidence and mortality were analyzed. Incidence rates were age-standardized against the 2001 Australian Standard Population. Mortality was assessed using log-rank and Cox regression. Results: From 1982 to 2014, there were 299 cases of conjunctival melanoma. The age-standardized incidence rate was 0.48 (95% confidence interval [CI] = 0.41 to 0.54) per million per year. Women (0.52, 95% CI = 0.42 to 0.62) had a higher incidence than men (0.42, 95% CI = 0.33 to 0.51). The incidence of conjunctival melanoma increased in men (+1.46%) and significantly women (+1.41%, P = 0.023) over the study period. The mean 5-, 10-, and 15-year disease-specific survival were 90%, 82%, and 80%, respectively, during the 33-year interval. Comparisons of survival among age, sex, and state revealed no significant differences when tested using log-rank or Cox regression. Conclusions: In conclusion, we found an increase in the rate of conjunctival melanoma diagnoses in Australia from 1982 to 2014. Over the same period, disease survival remained unchanged at a mean of 90%.
DOI
10.1167/iovs.64.14.2
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Incidence and mortality of conjunctival melanoma in Australia (1982 to 2014). Investigative Ophthalmology and Visual Science, 64(14), https://doi.org/10.1167/iovs.64.14.2