Document Type
Journal Article
Publication Title
Alzheimer's & Dementia: Translational Research & Clinical Interventions (TRCI)
Volume
10
Issue
2
Publisher
Wiley
School
School of Medical and Health Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
RAS ID
69789
Funders
National Health and Medical Research Council / Medical Research Future Fund / US Alzheimer’s Association / Lions Alzheimer’s Foundation / Alzheimer’s WA / Australian Research Council
Grant Number
NHMRC Numbers : APP2008064, GNT1197315, ARC Number : FL190100011
Grant Link
http://purl.org/au-research/grants/nhmrc/1197315 / http://purl.org/au-research/grants/arc/FL190100011
Abstract
INTRODUCTION: The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World-Wide FINGERS (WW-FINGERS). As part of WW-FINGERS, the Australian AU-ARROW study mirrors aspects of FINGER, as well as US-POINTER. METHOD: AU-ARROW is a randomized, single-blind, multisite, 2-year clinical trial (n = 600; aged 55–79). The multimodal lifestyle intervention group will engage in aerobic exercise, resistance training and stretching, dietary advice to encourage MIND diet adherence, BrainHQ cognitive training, and medical monitoring and health education. The Health Education and Coaching group will receive occasional health education sessions. The primary outcome measure is the change in a global composite cognitive score. Extra value will emanate from blood biomarker analysis, positron emission tomography (PET) imaging, brain magnetic resonance imaging (MRI), and retinal biomarker tests. DISCUSSION: The finalized AU-ARROW protocol is expected to allow development of an evidence-based innovative treatment plan to reduce cognitive decline and dementia risk, and effective transfer of research outcomes into Australian health policy. Highlights: Study protocol for a single-blind, randomized controlled trial, the AU-ARROW Study. The AU-ARROW Study is a member of the World-Wide FINGERS (WW-FINGERS) initiative. AU-ARROW's primary outcome measure is change in a global composite cognitive score. Extra significance from amyloid PET imaging, brain MRI, and retinal biomarker tests. Leading to development of an innovative treatment plan to reduce cognitive decline.
DOI
10.1002/trc2.12466
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
Gardener, S. L., Fuller, S. J., Naismith, S. L., Baker, L., Kivipelto, M., Villemagne, V. L., . . . Martins, R. N. (2024). The Australian multidomain approach to reduce dementia risk by protecting brain health with lifestyle intervention study (AU-ARROW): A study protocol for a single-blind, multi-site, randomized controlled trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions (TRCI), 10(2), article e12466. https://doi.org/10.1002/trc2.12466