Association between gamma glutamyl transpeptidase to HDL-cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy

Authors

Melanni L. Lizarbe-Lezama
Jhoel E. Rodriguez-Macedo
Daniel Fernandez-Guzman
Ana L. Alcantara-Diaz
Gustavo Salinas-Sedo
Carlos J. Toro-Huamanchumo, Edith Cowan UniversityFollow

Document Type

Journal Article

Publication Title

Diabetes & vascular disease research

Volume

21

Issue

3

PubMed ID

38702054

Publisher

Sage

School

Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences

RAS ID

71169

Funders

Forrest Research Foundation / Edith Cowan University

Comments

Lizarbe-Lezama, M. L., Rodriguez-Macedo, J. E., Fernandez-Guzman, D., Alcantara-Diaz, A. L., Salinas-Sedo, G., & Toro-Huamanchumo, C. J. (2024). Association between gamma glutamyl transpeptidase to HDL-Cholesterol (GGT/HDL-C) ratio and metabolic syndrome resolution after sleeve gastrectomy. Diabetes & Vascular Disease Research, 21(3), 14791641241252553. https://doi.org/10.1177/14791641241252553

Abstract

OBJECTIVE: To evaluate the association between GGT/HDL-C ratio and resolution of MetS in adults after sleeve gastrectomy (SG). METHODS: We conducted a retrospective cohort study using secondary data from a Peruvian bariatric center. The study population consisted of adults aged 18 and above who underwent laparoscopic SG and were diagnosed with MetS prior to the surgery. The main outcome measured was MetS resolution 6 months post-surgery and the exposure variable was the GGT/HDL-C ratio. RESULTS: We analyzed 137 patients with a mean age of 38.9 ± 10.9 years; 64.2% were females. The median GGT/HDL-C ratio was 1.1 [0.7 - 1.5], and 83.9% of patients experienced resolution of MetS. Furthermore, both the middle tertile of GGT/HDL-C (aRR: 1.28; 95% CI: 1.04 - 1.58; p = .019) and the lowest tertile (aRR: 1.27; 95% CI: 1.01 - 1.60; p = .038) showed a significant association with the resolution of MetS. CONCLUSION: Eight out of 10 patients undergoing SG experience resolution of MetS within 6 months after surgery. Patients in the middle and lower tertiles of the GGT/HDL-C were more likely to achieve this outcome. Therefore, the GGT/HDL-C ratio should be considered a valuable and efficient biomarker for preoperative assessment of bariatric surgery candidates.

DOI

10.1177/14791641241252553

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