Author Identifier (ORCID)
Abstract
Purpose: The purpose of this study is to identify activity profiles and their correlates in patients with localised renal cell carcinoma (RCC) and colorectal cancer (CRC) shortly after treatment completion.
Methods: In the ReLife (n = 326 patients with RCC) and EnCoRe (n = 358 patients with CRC) studies, we measured physical activity and sedentary behaviour at 3 months and 6 weeks after treatment completion using accelerometers. We used latent profile analyses to determine activity profiles. Demographic, lifestyle-related, and clinical correlates were investigated with multinomial regression analyses.
Results: We identified three activity profiles for both populations: a most sedentary (RCC:28%, CRC:16%), an average (RCC:50%, CRC:53%), and a highly active profile (RCC:22%, CRC:31%). In the most sedentary profile, mean sedentary time was 11.9 h/day for RCC and 13.1 h/day for CRC, while mean physical activity was 72 min/day and 44 min/day, respectively. Correlates of the most sedentary profile were male sex (RCC: odds ratio (OR), 2.18; 95% confidence interval [95%CI], 1.06–4.47), and higher fatigue scores (per 1 point: RCC, 0.98 [0.96–1.00]; CRC, 0.98 [0.96–0.99]). Correlates of the highly active profile were male sex (CRC, 0.38 [0.20–0.71]), higher educational level (RCC, 0.31 [0.14–0.72]; CRC, 0.46 [0.22–0.96]), and higher BMI (per 1 kg/m2: RCC, 0.91 [0.84–0.99]; CRC, 0.92 [0.86–0.99]).
Conclusions: There are distinct activity profiles in patients with RCC and CRC. Male sex, higher education, higher BMI, and lower fatigue score were associated with less favourable profiles.
Implications for Cancer Survivors: These findings highlight that activity profiles in patients with RCC and CRC are heterogeneous, which should be considered when promoting healthy lifestyles.
Keywords
cancer survivorship, colorectal cancer, lifestyle, physical activity, renal cell carcinoma, sedentary behaviour
Document Type
Journal Article
Date of Publication
1-1-2026
E-ISSN
19322267
ISSN
19322259
PubMed ID
42693363
Publication Title
Journal of Cancer Survivorship
Publisher
Springer
School
Exercise Medicine Research Institute
Funding Information
Funding for this current project is provided by the World Cancer Research Fund (IIG_FULL_2023_020). The ReLife study has previously received funding from the Dutch Cancer Society (KUN 2015-7948). The EnCoRe study has previously received funding from the Dutch Cancer Society (KWF Kankerbestrijding, grant no. 2021-1/13387), Stichting Alpe d’Huzes within the research programme “Leven met kanker” of the Dutch Cancer Society grants UM 2010–4867 and UM 2012–5653, by ERA-NET on Translational Cancer Research (TRAN‑SCAN: Dutch Cancer Society (UM 2014–6877), by the World Cancer Research Fund (WCRF: 2017/1619 and WCRF: 2016/1620), and by Kankeronderzoekfonds Limburg as part of Health Foundation Limburg grant 00005739.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Siffels, A., Bours, M. J. L., Van Roekel, E. H., Weijenberg, M. P., Sedelaar, J. P. M., Breukink, S. O., Keulen, E. T. P., Janssen-Heijnen, M., Frenken, K. G., Aben, K. K. H., Maurits, J. S. F., Kiemeney, L. a. L. M., Buffart, L. M., & Vrieling, A. (2026). Activity profiles and their correlates in patients with localised renal and colorectal cancer shortly after treatment: A cross-sectional analysis. Journal of Cancer Survivorship. Advance online publication. https://doi.org/10.1007/s11764-026-02106-1