Document Type
Journal Article
Publication Title
Journal of Medical Case Reports
Volume
15
Issue
1
Publisher
Springer Nature / BMC
School
School of Medical and Health Sciences
RAS ID
39611
Funders
Bendat Respiratory Research and Development Fund in-kind funding
Abstract
Background: Immunotherapy has become an efficacious option in the management of solid organ malignancies. Immune-related adverse events including pneumonitis are well described and may be particularly of concern in patients receiving immunotherapy for non-small-cell lung cancer. Case presentations: In this paper, we describe three cases of immunotherapy-induced pneumonitis occurring in the management of lung malignancy. Our cases include a 54-year-old Caucasian woman with squamous cell lung cancer who was successfully rechallenged with immunotherapy after prior significant pneumonitis, a 65-year-old Caucasian man with metastatic squamous cell lung cancer who developed pneumonitis after multiple cycles of uneventful immunotherapy, and a 73-year-old Caucasian man with squamous cell lung cancer who developed early-onset pneumonitis with rebound on steroid taper. Conclusions: This case series has provided further insight into the presentation and risk factors for pneumonitis in patients with non-small-cell lung cancer. Each of the cases of immunotherapy-induced pneumonitis illustrates the different potential patterns that may arise when immunotherapy-induced pneumonitis develops. This case series provides key learning points that may assist physicians managing non-small-cell lung cancer with immunotherapy.
DOI
10.1186/s13256-021-02926-y
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Picard, S., Goh, D., Tan, A., Sikotra, N., Gabbay, E., & Clay, T. (2021). Patterns of immunotherapy-induced pneumonitis in patients with non-small-cell lung cancer: A case series. Journal of Medical Case Reports, 15, article 332. https://doi.org/10.1186/s13256-021-02926-y