Document Type

Journal Article

Publication Title

Diagnostics

Volume

11

Issue

12

Publisher

MDPI

School

School of Medical and Health Sciences

RAS ID

42683

Comments

Shaikh, M. S., Zafar, M. S., Saleem, F., Alnazzawi, A., Lone, M. A., Bukhari, S. J. A., & Khurshid, Z. (2021). Host defence peptides in diabetes mellitus type 2 patients with periodontal disease. A systematic review. Diagnostics, 11(12), article 2210.

https://doi.org/10.3390/diagnostics11122210

Abstract

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 cross‐sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

DOI

10.3390/diagnostics11122210

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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Dentistry Commons

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