Bioactivity of zirconium-substituted nanobioactive glass particles

Document Type

Journal Article


Taylor and Francis Inc.


Electron Science Research Institute




Originally published as: Prabhu, M., Kavitha, K., Sutha, S., Manivasakan, P., Rajrendran, V., Kulandaivelu, P., Alameh, K. (2015). Bioactivity of zirconium-substituted nanobioactive glass particles in Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 45(1), 92-96. Available here.


In this study, zirconium substituted nanobioactive glass particles with compositions, namely, 58SiO2-33CaO-9P2O5 and 58SiO2-28CaO-9P 2O5-5ZrO2 were synthesized using sol-gel method. The prepared samples were characterized before and after in vitro studies using different techniques namely X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. The prepared samples reveal amorphous nature and spherical shape with an average particle size of less than 100 nm. Specific surface area of the samples found to be 90.69 and 81.20 m2g-1, respectively, for without and with nano ZrO2 metal oxides. The formation of hydroxyapatite layer on the surface of the glass during in vitro studies after 21 days of immersion in simulated body fluid on without ZrO2 sample was confirmed by the X-ray diffraction pattern. Further, studies required for the optimization of the composition for need based applications, such as regenerative dentistry and bone implant.