Document Type

Journal Article

Publisher

Public Library of Science

School

School of Medical Sciences

RAS ID

20845

Comments

This article was originally published as : Collins, L. M., Begeti, F., Panin, F., Lazar, A. S., Cruickshank, T., Ziman, M., ... & Barker, R. A. (2015). Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington’s Disease. PLoS currents,7.

Abstract

Background: We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington’s disease (HD) patients to detect and quantify motor impairments at all stages of thedisease. Methods: Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn. Results: We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores. Conclusion: This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies. © 2015, Public Library of Science. All Rights Reserved.

DOI

10.1371/currents.hd.ded251617ae62a1364506b0521bd3761

Creative Commons License

Creative Commons Attribution 3.0 License
This work is licensed under a Creative Commons Attribution 3.0 License.

Share

 
COinS