Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population
Document Type
Journal Article
Publisher
Japan Endocrine Society
Place of Publication
Kyoto, Japan
School
School of Medical and Health Sciences
RAS ID
19920
Abstract
MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters. This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population. Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected. The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform. Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS. There are three SNPs significantly associated with MetS. The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25, P
DOI
10.1507/endocrj.EJ15-0236
Access Rights
free_to_read
Comments
Yan, Y., We, L., Wang, S., Wang, W., Dong, J., & He, Y. (2015). Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population. Endocrine Journal, 62(10). 887-896. . Available here