Document Type

Journal Article

Publisher

BMJ Publishing Group

Faculty

Faculty of Health, Engineering and Science

School

School of Medical Sciences

RAS ID

17715

Comments

This article was originally published as: Lai Q., Wang T., Guo Q., Zhang Y., Wang Y., Yuan L., Ling R., He Y., Wang W. (2014). Positive correlation between the expression of hEag1 and HIF-1α in breast cancers: An observational study. BMJ Open, 4(5), e005049. Original article available here

Abstract

Objectives: To explore the expression patterns of Eag1 (ether á go-go 1) and HIF-1α (hypoxia-inducible factor 1α) in a cohort of patients with breast cancer. Setting: Department of general surgery in an upper first-class hospital in Xi'an, China. Participants: A total of 112 female Han Chinese patients with a diagnosis of invasive ductal carcinoma were included. Patients with main internal diseases, such as cardiovascular, endocrine, gastroenterological, haematological, infectious diseases, etc, were excluded. Primary and secondary outcome measures: Expression profiles of Eag1 and HIF-1α. Results: Eag1 and HIF-1α were overexpressed in the tumour tissues compared with the pair-matched control tissues, p=0.002 and <0.001, respectively. The expression of Eag1 and HIF-1α was negatively correlated with tumour size, p=0.032 and p=0.025, respectively, and lymph node status (p=0.040, p=0.032, respectively). The coexpression of Eag1 and HIF-1α was correlated with tumour size ( p=0.012), lymph node status (p=0.027) and tumour stage (p=0.036). HIF-1α has a strong correlation with hEag1 expression (κ=0.731, p<0.001). Conclusions: HIF-1á expression has a strong correlation with hEag1 expression. We are the first to attempt to explore the correlation at the population level.

DOI

10.1136/bmjopen-2014-005049

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

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