β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men

Author Identifier

Ralph Martins

https://orcid.org/0000-0002-4828-9363

Document Type

Journal Article

Publication Title

The American Journal of Geriatric Psychiatry

Publisher

Elsevier

Place of Publication

United States

School

School of Medical and Health Sciences

RAS ID

22261

Funders

National Health and Medical Research Council

Grant Number

NHMRC Number : 1009292

Comments

Holmes, S. E., Esterlis, I., Mazure, C. M., Lym. Y. Y., Ames, D., Rainey-Smith, S., . . . Pietrzak, R. H. (2016). β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men. American Journal of Geriatric Psychiatry, 24(12), 1191-1195.

https://doi.org/10.1016/j.jagp.2016.08.007

Abstract

Objective:

To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men.

Methods:

Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms.

Results:

Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29).

Conclusion:

Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.

DOI

10.1016/j.jagp.2016.08.007

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