Document Type
Journal Article
Publisher
BMJ Group
School
School of Medical and Health Sciences
RAS ID
27095
Funders
National Institute on Aging (AG-9775, AG-21079 and AG-033285)
Vilas Estate Trust
National Science Foundation
Spencer Foundation
Graduate School of the University of Wisconsin-Madison
Abstract
Objectives:
This study examined how environmental, health, social, behavioural and genetic factors interact to contribute to myocardial infarction (MI) risk.
Design:
Survey data collected by Wisconsin Longitudinal Study (WLS), USA, from 1957 to 2011, including 235 environmental, health, social and behavioural factors, and 77 single- nucleotide polymorphisms were analysed for association with MI. To identify associations with MI we utilized recursive partitioning and random forest prior to logistic regression and chi-squared analyses.
Participants:
6198 WLS participants (2938 men; 3260 women) who (1) had a MI before 72 years and (2) had a MI between 65 and 72 years.
Results:
In men, stroke (LR OR: 5.01, 95% CI 3.36 to 7.48), high cholesterol (3.29, 2.59 to 4.18), diabetes (3.24, 2.53 to 4.15) and high blood pressure (2.39, 1.92 to 2.96) were significantly associated with MI up to 72 years of age. For those with high cholesterol, the interaction of smoking and lower alcohol consumption increased prevalence from 23% to 41%, with exposure to dangerous working conditions, a factor not previously linked with MI, further increasing prevalence to 50%. Conversely, MI was reported in
Conclusions:
Together these results indicate important differences in factors associated with MI between the sexes, that combinations of factors greatly influence the likelihood of MI, that MI-associated factors change and associations weaken after 65 years of age in both sexes, and that the limited genotypes assessed were secondary to environmental, health, social and behavioral factors.
DOI
10.1136/bmjopen-2016-011529
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Comments
Gonzales, T. K., Yonker, J. A., Chang, V., Roan, C. L., Herd, P., & Atwood, C. S. (2017). Myocardial infarction in the Wisconsin Longitudinal Study: The interaction among environmental, health, social, behavioural and genetic factors. BMJ Open, 7(1), Article e011529.
http://dx.doi.org/10.1136/bmjopen-2016-011529