Document Type

Journal Article

Publisher

Sci Forschen

School

School of Medical Sciences/Centre of Excellence in Alzheimer's Disease Research and Care

RAS ID

21735

Comments

Originally published as: Martins, I. J. (2016). Diet and nutrition reverse Type 3 diabetes and accelerated aging linked to global chronic diseases. Journal of Diabetes Research and Therapy, 2(2). Original article available here

Abstract

The acceleration in the rate of chronic diseases that involve insulin resistance has become of global concern. The rate of the most prevalent chronic disease such as cardiovascular disease is linked to the metabolic syndrome, non alcoholic fatty liver disease (NAFLD) and other chronic diseases that include obesity, diabetes and neurodegenerative diseases. The gene-environment interaction in Western countries indicates that with urbanization access to food and its content may lead to induction of epigenetic alterations and identify the gene Sirtuin 1 (Sirt 1) to be responsible for the increased risk for insulin resistance and NAFLD relevant to Type 1, Type 2 and Type 3 diabetes in these countries. Nutrigenomics is linked to neuron and liver telomere maintenance, cell division and tissue growth and has become important with essential nutrients that regulate Sirt 1 function important to prevent NAFLD in individuals with diabetes. Nutrigenomic diets, exercise, drugs and lifestyle changes regulate Type 3 diabetes with neuron Sirt 1 transcriptional responses associated with DNA modifications that regulate brain insulin resistance relevant to NAFLD and diabetes.

DOI

10.16966/2380-5544.117

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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Diseases Commons

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