Document Type
Journal Article
Publisher
MDPI
School
School of Medical and Health Sciences
RAS ID
25082
Funders
National Natural Science Foundation of China (81370083, 81673247)
the National Natural Sciences Foundation of China (NSFC)-Australian National Health and Medical Research Council (NHMRC) Joint Research Project
Beijing Nova Program (Z141107001814058)
Grant Number
NHMRC Number : 1112767
Abstract
Background
DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer.
Materials and Methods
Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016. Indirect comparison meta-analysis was used to evaluate the diagnostic value of the included candidate genes.
Results
The systematic literature search yielded a total of 33 studies including a total of 4801 subjects (2238 patients with lung cancer and 2563 controls) and covering 32 genes. We identified that methylated genes in sputum samples for the early screening and auxiliary detection of lung cancer yielded an overall sensitivity of 0.46 (0.41–0.50) and specificity of 0.83 (0.80–0.86). Combined indirect comparisons identified the superior gene of SOX17 (sensitivity: 0.84, specificity: 0.88), CDO1 (sensitivity: 0.78, specificity: 0.67), ZFP42 (sensitivity: 0.87, specificity: 0.63) and TAC1 (sensitivity: 0.86, specificity: 0.75).
Conclusions
The present meta-analysis demonstrates that methylated SOX17, CDO1, ZFP42, TAC1, FAM19A4, FHIT, MGMT, p16, and RASSF1A are potential superior biomarkers for the screening and auxiliary detection of lung cancer.
DOI
10.3390/ijerph14070679
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Liu, D., Peng, H., Sun, Q., Zhao, Z., Yu, X., Ge, S., ... & Wu, L. (2017). The indirect efficacy comparison of DNA methylation in sputum for early screening and auxiliary detection of lung cancer: A meta-analysis. International journal of environmental research and public health, 14(7), 679.
https://doi.org/10.3390/ijerph14070679