Title

Muscle mass as a target to reduce fatigue in patients with advanced cancer

Document Type

Journal Article

Publisher

Wiley Blackwell

Place of Publication

Germany

School

Exercise Medicine Research Institute

RAS ID

25081

Comments

Originally published as: Neefjes, E. C., Hurk, R. M., Blauwhoff‐Buskermolen, S., Vorst, M. J., Becker‐Commissaris, A., Schueren, M. A., ... & Verheul, H. M. (2017). Muscle mass as a target to reduce fatigue in patients with advanced cancer. Journal of cachexia, sarcopenia and muscle, 8(4), 623-629. Available here.

Abstract

Background: Cancer-related fatigue (CRF) reduces quality of life and the activity level of patients with cancer. Cancer related fatigue can be reduced by exercise interventions that may concurrently increase muscle mass. We hypothesized that low muscle mass is directly related to higher CRF. Methods: A total of 233 patients with advanced cancer starting palliative chemotherapy for lung, colorectal, breast, or prostate cancer were studied. The skeletal muscle index (SMI) was calculated as the patient's muscle mass on level L3 or T4 of a computed tomography scan, adjusted for height. Fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-fatigue questionnaire (cut-off for fatigue

DOI

10.1002/jcsm.12199

Access Rights

free_to_read

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