Document Type
Journal Article
Publisher
Canadian Center of Science and Education
School
School of Medical and Health Sciences / Centre for Excellence in Alzheimer's Disease Research and Care
RAS ID
23074
Funders
Edith Cowan University
McCusker Alzheimer's Research Foundation
National Health and Medical Research Council
Abstract
Food and nutrition guidelines for the handling and processing of fresh fruit, bread, and vegetables are essential and fresh produce may require cold preservation procedures to prevent minimal bacterial and fungi contamination of food. Bacterial lipopolysaccharides (LPS) corrupt lipoprotein and amyloid beta (Aβ) metabolism in diabetes, Alzheimer’s disease (AD) and various neurological diseases. In the developing world the increased plasma LPS levels induce non-alcoholic fatty liver diseases and interfere with albumin and Aβ interactions with spontaneous Aβ oligomer formation in the cerebrospinal fluid and brain that leads to neuronapoptosis by inactivation of Starling’s equation that is responsible for the maintenance of hydrostatic and oncotic pressure with relevance to fluid balance. In the developing world increased levels of LPS, mycotoxin and xenobiotics lead to irreversible neurological diseases by inhibition of Starling’s equation for maintenance of oncotic/osmotic pressure that lead to neuron senescence or apoptosis. In the developed world nutrigenomic diets are required that prevent Sirtuin 1 gene repression and maintain neuron survival that links the brain and peripheral hepatic monomer Aβ metabolism. The maintenance of blood-cerebrospinal fluid capillary transport of albumin and monomer Aβ is relevant to stabilization of neurons not only in Alzheimer’s disease but also in Type 3 diabetes and various neurological diseases. Healthy diets reverse the inhibition of brain to peripheral Aβ transport that is sensitive to Starling’s equation for regulation of central nervous system hydrostatic and oncotic pressure with the prevention of diabetes, various neurological diseases and Alzheimer’s disease.
DOI
10.5539/jfr.v5n6p45
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Martins, I. J. (2016). Food quality induces a miscible disease with relevance to Alzheimer’s disease and Neurological diseases. Journal of Food Research, 5(6), 45.
https://doi.org/10.5539/jfr.v5n6p45