Document Type
Journal Article
Publisher
European - American Journals
School
School of Medical and Health Sciences / Centre for Excellence in Alzheimer's Disease Research and Care
RAS ID
23075
Funders
Edith Cowan University
McCusker Alzheimer's Research Foundation
National Health and Medical Research Council
Abstract
In the global world diabetes and mitochondrial disease is expected to cost the developing world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid beta clearance pathway is now relevant to amyloid beta induced mitochondrial apoptosis. The quality of food consumed has raised major concerns with increased levels of plasma bacterial lipopolysaccharides (LPS) that induces amyloid beta aggregation and mitochondrial apoptosis with programmed cell death linked to non alcoholic fatty liver disease (NAFLD) and many organ diseases. The amount, nature and time of day of fat consumption in diabetes has become important with relevance to caffeine metabolism, brain toxic amyloid beta oligomer formation and neuron apoptosis. To prevent programmed cell death dietary fat and caffeine consumption need to be revised to allow rapid hepatic caffeine and amyloid beta metabolism with the prevention of global mitophagy associated with diabetes, NAFLD and neurodegenerative diseases.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Comments
Martins, I. J. (2016). Food intake and caffeine determine amyloid beta metabolism with relevance to mitophagy in brain aging and chronic disease. European Journal of Food Science and Technology, 4(5), 11-17.
https://www.eajournals.org/journals/european-journal-of-food-science-and-technology-ejfst/vol-4-issue-5-december-2016/