Title

Physical activity in preventing Alzheimer’s Disease and cognitive decline: A narrative review

Document Type

Journal Article

Publisher

Adis International Ltd.

Place of Publication

New Zealand

School

School of Medical and Health Sciences

RAS ID

25411

Comments

Originally published as: Brini, S., Sohrabi, H. R., Peiffer, J. J., Karrasch, M., Hämäläinen, H., Martins, R. N., & Fairchild, T. J. (2017). Physical Activity in Preventing Alzheimer’s Disease and Cognitive Decline: A Narrative Review. Sports Medicine, 1-16. Original article available here.

Abstract

A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer’s disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations. The interaction between PA and the putative mechanisms underlying AD progression, including genetic factors and amyloid-β levels will be explored. In this context, particular attention will be given to studies assessing PA in the early clinical and preclinical, asymptomatic stages of AD. Based on current evidence, clinical considerations for implementation of exercise-based interventions are discussed, along with limitations of previous research and directions for future studies.

DOI

10.1007/s40279-017-0787-y

Access Rights

not_free_to_read

Share

 
COinS