Title

Cannabis teratology explains current patterns of Coloradan congenital defects: The contribution of increased cannabinoid exposure to rising teratological trends [Dataset]

Author Identifiers

Albert Stuart Reece

https://orcid.org/0000-0002-3256-720X

Gary Kenneth Hulse

https://orcid.org/0000-0002-7907-0233

Collection Type

Dataset

Upload Date

2019

School or Research Centre

School of Medical and Health Sciences

Publisher

Digital Science

Description

Rising Δ9-tetrahydrocannabinol concentrations in modern cannabis invites investigation of the teratological implications of prenatal cannabis exposure. Data from Colorado Responds to Children with Special Needs (CRCSN), National Survey of Drug Use and Health, and Drug Enforcement Agency was analyzed. Seven, 40, and 2 defects were rising, flat, and falling, respectively, and 10/12 summary indices rose. Atrial septal defect, spina bifida, microcephalus, Down’s syndrome, ventricular septal defect, and patent ductus arteriosus rose, and along with central nervous system, cardiovascular, genitourinary, respiratory, chromosomal, and musculoskeletal defects rose 5 to 37 times faster than the birth rate (3.3%) to generate an excess of 11 753 (22%) major anomalies. Cannabis was the only drug whose use grew from 2000 to 2014 while pain relievers, cocaine, alcohol, and tobacco did not. The correlation of cannabis use with major defects in 2014 (2019 dataset) was R = .77, P = .0011. Multiple cannabinoids were linked with summary measures of congenital anomalies and were robust to multivariate adjustment.

File Format(s)

PDF

File Size

1.69 MB

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