Genetic Analysis of MAPT Haplotype Diversity in Frontotemporal Dementia

Document Type

Journal Article

Publisher

Elsevier Inc.

Faculty

Faculty of Health and Science

School

School of Exercise, Biomedical and Health Science / Centre of Excellence in Alzheimer’s Disease Research

RAS ID

6309

Comments

Laws, S. , Friedrich, P., Diehl-Schmid, J., Muller, J., Ibach, B., Bauml, J., Eisele, T., Forstl, H., Kurz, A., & Riemenschneider, M. (2008). Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. Neurobiology of Aging, 29(8), 1276-1278. Available here

Abstract

The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.

DOI

10.1016/j.neurobiolaging.2007.02.019

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Link to publisher version (DOI)

10.1016/j.neurobiolaging.2007.02.019