Fibre Diffraction of Hair can Provide a Screening Test for Alzheimer's Disease: a Human and Animal Model Study
Veronica James, Australian National University
Jill Richardson, GlaxoSmithKline, UK
Terry Robertson, University of Western Australia
John Papadimitriou, University of Western Australia
Nichole Dutton, University of Western Australia
Moira Maley, University of Western Australia
Lev Berstein, N.N.Petrov Research Institute of Oncology, Russia
Olga Lantseva, Research Institute of Obstetrics and Gynecology
Ralph Martins, Edith Cowan University
Medical Science International Publishing
Faculty of Computing, Health and Science
School of Exercise, Biomedical and Health Science
Studies of molecular changes in hair as possible biomarkers for specific cancers revealed an additional molecular change in the diffraction patterns of some persons aged over 75. This change was found to correlate with the presence of Alzheimer's disease. To confirm this correlation and its relation to the presence of a human APP mutation known to definitely cause AD, hairs were examined from AD patients, pregnant women known to have an increase in in plasma beta amyloid and transgenic mice carrying a mutated human APP gene.
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