Title

Androgen receptor content following heavy resistance exercise in men

Document Type

Journal Article

Faculty

Faculty of Computing, Health and Science

School

School of Exercise, Biomedical and Health Science / Centre for Alzheimer's Disease

RAS ID

9226

Comments

Ratamess, N. A., Kraemer, W. J., Volek, J. S., Maresh, C. M., VanHeest, J. L., Sharman, M. J., ... & Hatfield, D. L. (2005). Androgen receptor content following heavy resistance exercise in men. The Journal of steroid biochemistry and molecular biology, 93(1), 35-42.

Abstract

The purpose of the present investigation was to examine androgen receptor (AR) content in the vastus lateralis following two resistance exercise protocols of different volume. Nine resistance-trained men (age = 24.3 ± 4.4 years) performed the squat exercise for 1 (SS) and 6 sets (MS) of 10 repetitions in a random, counter-balanced order. Muscle biopsies were performed at baseline, and 1 h following each protocol. Blood was collected prior to, immediately following (IP), and every 15 min after each protocol for 1 h. No acute elevations in serum total testosterone were observed following SS, whereas significant 16–23% elevations were observed at IP, 15, and 30 min post-exercise following MS. No acute elevations in plasma cortisol were observed following SS, whereas significant 31–49% elevations were observed for MS at IP, 15, and 30 min post-exercise. Androgen receptor content did not change 1 h following SS but significantly decreased by 46% following MS. These results demonstrated that a higher volume of resistance exercise resulted in down-regulation of AR content 1 h post-exercise. This may have been due to greater protein catabolism associated with the higher level of stress following higher-volume resistance exercise.

DOI

10.1016/j.jsbmb.2004.10.019

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Link to publisher version (DOI)

10.1016/j.jsbmb.2004.10.019