Oligomerization and Toxicity of Aβ Fusion Proteins
Faculty of Computing, Health and Science
School of Medical Sciences / Centre of Excellence for Alzheimer's Disease Research and Care
This study has found that the Maltose binding protein Aβ42 fusion protein (MBP-Aβ42 ) forms soluble oligomers while the shorter MBP-Aβ16 fusion and control MBP did not. MBP-Aβ42. but neither MBP-Aβ16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells, This study demonstrates the potential utility of MBP-Aβ42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further Aβ42 characterization.