Document Type

Journal Article


Cambridge University Press/The Nutrition Society


Faculty of Computing, Health and Science


School of Exercise and Health Sciences




This is an Author's Accepted Manuscript of: Hodgson, J., Zhu, K., Lewis, J., Kerr, D., Meng, X., Solah, V., Devine, A. , Binns, C., Woodman, R., & Prince, R. (2012). Long-term effects of a protein-enriched diet on blood pressure in older women. British Journal of Nutrition: an international journal of nutritional science , 107(11), 1664-1672. Available here


Short-term randomised, controlled trials have found that dietary protein relative to carbohydrate can reduce blood pressure. Our objective was to investigate the effects on blood pressure of an increase in protein intake from whey over 2 years in women aged over 70 years. From the general population, 219 women aged between 70 and 80 years were recruited to a 2-year randomised, double-blind, placebo-controlled parallel-design trial: 181 women completed the trial to the end of year 2. Participants were randomly assigned to consume a daily whey protein-based beverage (protein) or an energy-matched low-protein high-carbohydrate beverage (control). Blood pressure measurements were performed at baseline, year 1 and year 2. For protein relative to control, the estimated mean net differences in protein and carbohydrate intakes were 18 (95% CI 13, 23) and 222 (95% CI 29, 235) g/d at year 1, and 22 (95% CI 17, 28) and 218 (95% CI 26, 231) g/d at year 2. Intention-to-treat analysis found no overall differences between groups in blood pressure (P.0•5). Net differences in systolic and diastolic blood pressure were 22•3 (95% CI 25•3, 0•7) and 21•5 (95% CI 23•6, 0•6)mmHg at year 1, and 1•6 (95% CI 21•5, 4•7) and 0•3 (95% CI 21•9, 2•4)mmHg at year 2. Similar differences in systolic and diastolic blood pressure at years 1 and 2 were observed with per-protocol analysis. Therefore, the present study did not provide evidence that a higher whey protein intake in older women can have prolonged effects on blood pressure.



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