World Journal of Stem Cells
Baishideng Publishing Group
School of Medical and Health Sciences
National Natural Science Foundation of China, No. 81471081 / Natural Science Foundation of Fujian Province, China, No. 2019J01010 / Xiamen Research Foundation for Science and Technology Project No. 3502Z20194037 / Scientific Research Foundation for Advanced Talents / Xiang’an Hospital of Xiamen University, No. PM201809170005
In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore, the replacement of destroyed functional β cells with insulin-secreting cells derived from functional stem cells is a good idea as a new therapeutic idea. This review introduces the development schedule of mouse and human embryonic islets. The differences between mouse and human pancreas embryo development were also listed. Accordingly to the different sources of stem cells, the important research achievements on the differentiation of insulin-secreting β cells of stem cells and the current research status of stem cell therapy for diabetes were reviewed. Stem cell replacement therapy is a promising treatment for diabetes, caused by defective insulin secretion, but there are still many problems to be solved, such as the biosafety and reliability of treatment, the emergence of tumors during treatment, untargeted differentiation and autoimmunity, etc. Therefore, further understanding of stem cell therapy for insulin is needed.
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