Document Type
Journal Article
Publication Title
Gene
Volume
842
PubMed ID
35961436
Publisher
Elsevier
School
School of Medical and Health Sciences
RAS ID
47180
Abstract
Consistent evidence from observational studies supports a risk-increasing association between post-traumatic stress disorder (PTSD) and coronary artery disease (CAD); however, the mechanisms underlying their relationship remain poorly understood. This study assesses the genetic correlation and potential causal relationship between PTSD and CAD-related traits. We analysed genome-wide associated study summary data of PTSD (cases = 23,212, controls = 151,447) with CAD-related traits (sample size up to 408,458 individuals) to achieve our study objectives. Findings revealed a significant and positive genetic correlation between PTSD and CAD (rG = 0.19, p = 3.47 × 10 – 2), and between PTSD and CAD traits of ischemic heart disease (genetic correlation [rG] = 0.42, p = 5.17 × 10 – 10), coronary arteriosclerosis (rG = 0.32, p = 3.78 × 10 – 7), and angina pectoris (rG = 0.48, p = 1.14 × 10–9). However, Mendelian randomisation (MR) analysis found no evidence for a significant causal association between PTSD and CAD traits, regardless of analysis direction (PTSD or CAD traits as the exposure or outcome variable). Findings from MR sensitivity analyses were consistent, suggesting that genetic liability to PTSD has no causal influence on any CAD trait and vice versa. In summary, our study provides evidence implicating a positive genetic correlation between PTSD with CAD-related traits, supporting evidence of a risk-increasing but non-causal association between them.
DOI
10.1016/j.gene.2022.146802
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Comments
This is an authors accepted manuscript version of an article published by Elsevier, in Gene.
Akosile, W., & Adewuyi, E. (2022). Genetic correlation and causality assessment between post-traumatic stress disorder and coronary artery disease-related traits. Gene, 842, article 146802. https://doi.org/10.1016/j.gene.2022.146802