Measures of carotid atherosclerosis and fall-related hospitalization risk: The Perth Longitudinal Study of Ageing Women
Nutrition, Metabolism and Cardiovascular Diseases
Nutrition and Health Innovation Research Institute / School of Medical and Health Sciences
National Health and Medical Research Council (NHMRC) / Rebecca L. Cooper Medical Research Foundation / Healthway the Western Australian Health Promotion Foundation / Royal Perth Hospital Research Foundation Career Advancement Fellowship (CAF 130/2020) / Emerging Leader Fellowship, Western Australian Future Health Research and Innovation Fund, Department of Health / National Heart Foundation of Australia Future Leader Fellowship (ID: 102817) / Royal Perth Hospital Research Foundation ‘Lawrie Beilin’ Career Advancement Fellowship (ID: CAF 127/2020)
NHMRC Numbers : 254627, 303169, 572604, GNT1197958
http://purl.org/au-research/grants/nhmrc/254627 http://purl.org/au-research/grants/nhmrc/303169 http://purl.org/au-research/grants/nhmrc/572604 http://purl.org/au-research/grants/nhmrc/1197958
Background and aims: We and others have identified links between cardiovascular conditions and poor musculoskeletal health. However, the relationship between measures of carotid atherosclerosis such as focal carotid plaque and common carotid intima media thickness (CCA-IMT) and falls remains understudied. This study examined the association between measures of carotid atherosclerosis and fall-related hospitalization over 11.5 years in community dwelling older women. Methods and results: 1116 older women recruited in 1998 to a five-year randomized controlled trial to examine the effect of calcium supplementation in preventing fracture and who had undertaken B-mode ultrasound in 2001 (three years after the baseline clinical visit) were included in this study. The participants were followed for over 11.5 years as Perth Longitudinal Study of Ageing Women (PLSAW). Over the follow up period, 428 (38.4 %) women experienced a fall-related hospitalization. Older women with carotid plaque had 44 % a higher relative hazard for fall-related hospitalization (HR 1.44; 95 % CI, 1.18 to 1.76) compared to those without carotid plaque. The association persisted after adjustment for established falls risk factors such as measures of muscle strength and physical function.Each SD increase in the mean and maximum CCA-IMT was also associated with a higher risk of fall-related hospitalizations (HR 1.10; 95 % CI, 1.00 to 1.21 and HR 1.11; 95 % CI, 1.01 to 1.22, respectively). Conclusions: Measures of carotid atherosclerosis are associated with a higher risk of fall-related hospitalization independent of established falls risk factors. These findings suggest the importance of vascular health when considering falls risk.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Available for download on Wednesday, January 31, 2024
This is an Authors Accepted Manuscript version of an article published by Elsevier in Nutrition, Metabolism and Cardiovascular Diseases. The published article is available at https://doi.org/10.1016/j.numecd.2022.10.003
Gebre, A. K., Sim, M., Dalla Via, J., Rodríguez, A. J., Hodgson, J. M., Bondonno, C. P., ... & Lewis, J. R. (2023). Measures of carotid atherosclerosis and fall-related hospitalization risk: The Perth Longitudinal Study of Ageing Women. Nutrition, Metabolism and Cardiovascular Diseases, 33(1), 95-104. https://doi.org/10.1016/j.numecd.2022.10.003