Interplay between foetal haemoglobin, micronutrients and oxidative stress biomarkers in sickle cell anaemia children
Human Nutrition & Metabolism
School of Medical and Health Sciences
Foetal haemoglobin (HbF) has been speculated to have an impact on the quantity of micronutrients and the latter also have a role to play in oxidative stress (OS) in sickle cell anaemia (SCA). No previous study in Ghana has examined the interplay of these factors together among SCA children. This study compared the levels of OS biomarkers (8-hydroxy-deoxyguanosine [8-OHdG] total antioxidant capacity [TAC]) and micronutrients (zinc and copper), and their relationship with HbF in SCA and sickle cell negative, apparently healthy children. This case-control study recruited 58 SCA (out-patients [n = 42] and in-patients [n = 16]) children aged 1–14 years as cases and 62 sickle cell negative children as controls from the Sickle Cell Unit at the Eastern Regional Hospital, Ghana. The micronutrients were measured using the atomic absorption spectrophotometer (AAS) whereas OS biomarkers and HbF were assayed using enzyme-linked immunosorbent assay (ELISA). SCA out-patients had a significantly higher level of HbF compared to HbA patients (p = 0.035). SCA in-patients had significantly increased levels of zinc, but a reduced 8-OHdG than SCA out-patients compared to control group (p < 0.05). HbF correlated significantly (r = 0.318, p < 0.038) with zinc in SCA out-patients. Micronutrients are essential in maintaining the redox status in SCA out-patients and HbF can influence some micronutrients.
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Owusu-Poku, A. G., Gyamfi, D., Togbe, E., Opoku, S., Ephraim, R. K. D., Asibey, J. G., . . . Addai-Mensah, O. (2022). Interplay between foetal haemoglobin, micronutrients and oxidative stress biomarkers in sickle cell anaemia children. Human Nutrition & Metabolism, 30, article 200173. https://doi.org/10.1016/j.hnm.2022.200173