Title
Exercise in advanced prostate cancer elevates myokine levels and suppresses in-vitro cell growth
Document Type
Journal Article
Publication Title
Prostate Cancer and Prostatic Diseases
Publisher
Nature
School
School of Medical and Health Sciences / Exercise Medicine Research Institute / Centre for Precision Health / Centre for Exercise and Sports Science Research
RAS ID
43941
Funders
Movember Foundation
National Health and Medical Research Council Centre for Research Excellence
Grant Number
NHMRC Number : APP1116334
Abstract
Background:
Altering the systemic milieu through exercise has been proposed as a potential mechanism underlying exercise-driven tumour suppression. It is not yet known whether men with advanced prostate cancer can elicit such adaptations following a program of exercise. The purpose is to examine myokine levels of serum acquired from metastatic castrate-resistant prostate cancer (mCRPC) patients recruited to the INTERVAL-GAP4 trial before and after 6 months of exercise and its tumour-suppressive effect.
Methods:
Twenty-five men with mCRPC (age = 74.7 ± 7.1 yrs) were randomised to supervised multimodal (aerobic and resistance) exercise (EX) or self-directed exercise control group (CON). Body composition was assessed using dual-energy x-ray absorptiometry (DXA), and fasting blood in a rested state was collected at baseline and at 6 months. Serum levels of myokines (SPARC, OSM, decorin, IGF-1, and IGFBP-3) were measured. Serum was applied to the prostate cancer cell line DU145, and growth was assessed for 72 h.
Results:
No significant change in body composition was observed. Adjusted serum OSM (P = 0.050) and relative OSM (P = 0.083), serum SPARC (P = 0.022) and relative SPARC (P = 0.025) increased in EX compared to CON. The area under curve (AUC) over 72 h showed a significant reduction in DU145 growth after applying post-intervention serum from the EX vs CON (P = 0.029).
Conclusion:
Elevated myokine expressions and greater tumour-suppressive effects of serum after 6 months of periodised and autoregulated supervised exercise was observed in men with mCRPC. Exercise-induced systemic changes may slow disease progression in men with advanced prostate cancer.
DOI
10.1038/s41391-022-00504-x
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
Kim, J. S., Taaffe, D. R., Galvão, D. A., Hart, N. H., Gray, E., Ryan, C. J., . . . Newton, R. U. (2022). Exercise in advanced prostate cancer elevates myokine levels and suppresses in-vitro cell growth. Prostate Cancer and Prostatic Diseases, 25, 86-92.
https://doi.org/10.1038/s41391-022-00504-x