Title

HLA repertoire of 115 UAE nationals infected with SARS-CoV-2

Document Type

Journal Article

Publication Title

Human Immunology

Volume

83

Issue

1

First Page

1

Last Page

9

PubMed ID

34462158

Publisher

Elsevier

School

School of Medical and Health Sciences

RAS ID

38930

Funders

Khalifa University of Science, Technology and Research

Comments

Alnaqbi, H., Tay, G. K., Jelinek, H. F., Francis, A., Alefishat, E., Chehadeh, S. E. H., ... & Alsafar, H. S. (2022). HLA repertoire of 115 UAE nationals infected with SARS-CoV-2. Human Immunology, 83(1), 1-9.

https://doi.org/10.1016/j.humimm.2021.08.012

Abstract

The class I and class II Human Leucocyte Antigens (HLA) are an integral part of the host adaptive immune system against viral infections. The characterization of HLA allele frequency in the population can play an important role in determining whether HLA antigens contribute to viral susceptibility. In this regard, global efforts are currently underway to study possible correlations between HLA alleles with the occurrence and severity of SARS-CoV-2 infection. Specifically, this study examined the possible association between specific HLA alleles and susceptibility to SARS-CoV-2 in a population from the United Arab Emirates (UAE). The frequencies of HLA class I (HLA-A, -B, and -C) and HLA class II alleles (HLA-DRB1 and -DQB1); defined using Next Generation Sequencing (NGS); from 115 UAE nationals with mild, moderate, and severe SARS-CoV-2 infection are presented here. HLA alleles and supertypes were compared between hospitalized and non-hospitalized subjects. Statistical significance was observed between certain HLA alleles and supertypes and the severity of the infection. Specifically, alleles HLA-B*51:01 and HLA-A*26:01 showed a negative association (suggestive of protection), whilst genotypes HLA-A*03:01, HLA-DRB1*15:01, and supertype B44 showed a positive association (suggestive of predisposition) to COVID-19 severity. The results support the potential use of HLA testing to differentiate between patients who require specific clinical management strategies.

DOI

10.1016/j.humimm.2021.08.012

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