Title

Changes in blood bone markers after the first and second bouts of whole-body eccentric exercises

Document Type

Journal Article

Publication Title

Scandinavian Journal of Medicine and Science in Sports

Volume

32

Issue

3

First Page

521

Last Page

532

PubMed ID

34951069

Publisher

Wiley

School

Centre for Exercise and Sports Science Research

RAS ID

42845

Funders

Ministry of Science and Technology, Taiwan

Grant Number

108‐2410‐H‐003‐116‐MY3

Comments

Huang, T. H., Nosaka, K., & Chen, T. C. (2022). Changes in blood bone markers after the first and second bouts of whole‐body eccentric exercises. Scandinavian journal of medicine & science in sports.

https://doi.org/10.1111/sms.14118

Abstract

The present study compared the first (EC1) and second (EC2) bouts of whole-body eccentric exercises to examine the effects of the magnitude of muscle damage on changes in blood bone markers. Fifteen sedentary young men performed nine eccentric exercises of arm, leg, and trunk muscles, and repeated them 2 weeks later. Blood samples were taken before and 2 h and 1–5 days following each bout to analyze plasma creatine kinase (CK) activity and myoglobin concentration, serum tartrate-resistant acid phosphatase (TRAP), type 1 C-terminal telopeptide (CTX-1), procollagen type I N-terminal propeptide (P1NP), bone-specific alkaline phosphatase (BAP), undercarboxylated-osteocalcin (ucOCN), carboxylated-osteocalcin (cOCN), and leptin concentrations. All except ucOCN changed significantly (p < 0.05) after both bouts. When comparing bouts for peak changes, P1NP (bone formation marker) and CTX-1 (bone resorption marker) increased less after EC2 (peak: 137±96% and 7±6%, respectively) than after EC1 (146 ± 80% and 30 ± 21%, respectively), whereas BAP (bone formation marker) increased more after EC2 (18 ± 16%) than after EC1 (4 ± 15%) (p < 0.05). Leptin (49 ± 58%) and cOCN (14 ± 10%) increased more (p < 0.05) after EC2 than after EC1 (−30 ± 15%, 9 ± 26%). Significant (p < 0.05) correlations were evident between peak CK activity and peak CTX-1 (r = 0.847), P1NP (r = 0.815), BAP (r = −0.707), ucOCN (r = 0.627), cCON (r = −0.759), and leptin (r = −0.740) changes after EC1, but many of these correlations disappeared after EC2. This was also found for the relationships between other muscle damage markers (myoglobin, muscle soreness, and muscle strength) and the bone markers. It was concluded that bone turnover was affected by eccentric exercise, but muscle damage was unfavorable for bone formation.

DOI

10.1111/sms.14118

Access Rights

subscription content

Research Themes

Health

Priority Areas

Exercise, nutrition, lifestyle and other interventions for optimal health across the lifespan

Share

 
COinS