Abstract

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.

Keywords

Maternal educational attainment, pregnancy, epigenome-wide DNA methylation changes, offspring, birth, adolescence

Document Type

Journal Article

Date of Publication

1-1-2023

Volume

29

PubMed ID

38052982

Publication Title

Molecular Psychiatry

Publisher

Nature

School

School of Medical and Health Sciences

RAS ID

64651

Funders

European Union's Horizon 2020 research and innovation program / Open Access funding provided by University of Oulu (including Oulu University Hospital).

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Comments

Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., . . . Sebert, S. (2023). Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence. Molecular Psychiatry, 29, 348-358. https://doi.org/10.1038/s41380-023-02331-5

First Page

348

Last Page

358

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Link to publisher version (DOI)

10.1038/s41380-023-02331-5